Immunomodulatory approaches to CNS injury: extracellular matrix and exosomes from extracellular matrix conditioned macrophages

Editorial: Brain Extracellular Space: Geometry, Matrix and Physiological Importance

Extracellular Matrix

The tissues of a multicellular organism contain two main components, the cells themselves, onwhichmost biological research has traditionally focused, and the material that lies between the cells. This material is called the extracellular matrix, usually abbreviated to ‘ECM’. The ratio of tissue volume occupied by ECM to that occupied by cells varies from less than 1:10 (e.g. in muscles) to more...

Transferring information from microtubules to extracellular matrix

Commentary to: Li S, Lei L, Somerville CR, Gu Y. Cellulose synthase interactive protein 1 (CSI1) links microtubules and cellulose synthase complexes. Proc Natl Acad Sci U S A 2012; 109:185– 90; PMID:22190487; http://dx.doi.org/10.1073/ pnas.1118560109 and Bringmann M, Li E, Sampathkumar A, Kocabek T, Hauser MT, Persson S. POM-POM2/cellulose synthase interacting1 is essential for the functional ...

Understanding the extracellular matrix

Tissue engineering deals with the growth and regeneration techniques of connective tissues or organs from a combination of cells and a scaffold to produce a functional organ. The engineering techniques therefore begin with an implantation of artificial materials, providing a proper environment for cells or tissues to be grown and functionalized. The scaffolds are often formulated with biodegrad...

Extracellular Matrix (ECM)

18.1 Context of the ECM ...................................................... 461 18.1.1 ECM – What’s in a Name? ............................................. 462 18.1.2 Old and New ECMs ........................................................ 462 18.1.3 Biophysical Considerations ............................................. 462 18.1.4 Jelly Bombs ................................................